Synergistic effect of anidulafungin combined with posaconazole in experimental aspergillosis
نویسندگان
چکیده
منابع مشابه
Posaconazole prophylaxis in experimental azole-resistant invasive pulmonary aspergillosis.
We investigated the efficacy of posaconazole prophylaxis in preventing invasive aspergillosis due to azole-resistant Aspergillus fumigatus isolates. Using a neutropenic murine model of pulmonary infection, posaconazole prophylaxis was evaluated using three isogenic clinical isolates, with posaconazole MICs of 0.063 mg/liter (wild type), 0.5 mg/liter (F219I mutation), and 16 mg/liter. A fourth i...
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BACKGROUND Few effective treatments for disseminated Aspergillus infections in dogs are available. Posaconazole has potent and broad-spectrum activity against Aspergillus spp., but its use has not yet been sufficiently evaluated in dogs. HYPOTHESIS/OBJECTIVES The aim of this study was to determine the safety and efficacy of posaconazole for the treatment of naturally occurring disseminated As...
متن کاملEfficacy of posaconazole and amphotericin B in experimental invasive pulmonary aspergillosis in dexamethasone immunosuppressed rats.
OBJECTIVES Invasive pulmonary aspergillosis is associated with high mortality. To assess new antifungal therapy options, animal models have to be developed to assess, in an appropriate setting, the activity of new drugs. METHODS Male albino CD rats (125-150 g) were fed with a protein-free diet and received dexamethasone thrice weekly subcutaneously during the whole experiment. After 2 weeks, ...
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We evaluated the combination of posaconazole with amphotericin B in vitro and in a murine model of systemic infections caused by Sporothrix brasiliensis and Sporothrix schenckii sensu stricto. In vitro data demonstrated a synergistic effect, and although posaconazole alone was effective against sporotrichosis, efficacy in terms of survival and burden reduction was increased with the combination...
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Background: The aim of this study was to investigate the effect of methanolic extract of Achillea millefolium L. (MEA) on the antiproliferative activity of bleomycin on human prostate cancer and normal skin cells. Materials and Methods: Human prostate cancer cell (DU-145) and human non-malignant fibroblast cell (HFFF2) were treated with MEA at various concentrations ( 20, 100, 500, 1000 and ...
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ژورنال
عنوان ژورنال: Medical Mycology
سال: 2016
ISSN: 1369-3786,1460-2709
DOI: 10.1093/mmy/myw110